Cross-coupling of diversified C(sp3) fragments with (hetero)aryl halides by upgrading Pd catalysis with the organocatalytic activation of amino acids KU Leuven
The success of Pd-catalyzed cross-coupling reactions in drug discovery has led to a large share of one- and two-dimensional drug scaffolds among pharmaceutical compounds. This leaves the three-dimensional medicinal compounds underexplored. In this project, we will tackle this issue by enabling the Pd-catalyzed cross-coupling of pharmaceutically relevant (hetero)aryl halides with amino acid-derived C(sp3) fragments. An innovative approach will ...