Projects
Development and application of filovirus reverse genetics systems for antiviral compound screening KU Leuven
Filoviruses are a rapidly expanding group of human pathogens known for their potential to cause severely debilitating disease with a high mortality rate. Several members of the family Filoviridae can cause filovirus disease but most outbreaks in the last five decades were attributable to the well-known Ebola virus and Marburg virus, the first filovirus to be discovered. Treatment options for Ebola virus disease and Marburg virus disease ...
Drug-induced cholestasis: in vitro detection and mechanistic insights. KU Leuven
Drug-induced liver injury (DILI) is the primary cause for the discontinuation of clinical trials and post-marketing withdrawal of drugs, leading to considerable losses for the pharmaceutical industry. Despite the immense financial losses that are related to DILI, its impact on patient healthcare is of much greater importance. Indeed, numerous cases have been reported in literature that illustrate the potentially fatal consequences of DILI. As ...
The marginal zone B cel in concordant xenograft rejection: critical help signals in the T cel-independent type II xenoantibody response and possible targets for xeno-immunosuppression. KU Leuven
Allogeneic hematopoietic stem cell transplantation
(HSCT) and posttransplant adoptive cell therapy with donor leukocyte infusions
(DLI) are known to exert potent graft-versus-leukemiaeffects and convincing
evidence is emerging that this approach can also elicit responses against solid
tumors. Graft-versus-leukemia effects specifically after DLI largely rely
on ...
Literature that bypassed the censor! The alternative literary circuit in Antwerp at the end of the seventeenth century. University of Antwerp
Beyond Petroleum. Reimagining Energy in Contemporary Film and Literature Ghent University
Like climate change, the shift to alternative energy sources is not just a technological challenge but a cultural issue too, necessitating a rethinking of dominant values, narratives and cultural ideas. One important development is the emergence of the ‘energy humanities’, a subfield that examines how cultural artefacts like movies and literary texts reflect on particular sources and uses of energy. Upon closer inspection, however, the field ...
Beyond Petroleum. Reimagining Energy in Contemporary Film and Literature KU Leuven
Like climate change, the shift to alternative energy sources is not just a technological challenge but a cultural issue too, necessitating a rethinking of dominant values, narratives and cultural ideas. One important development is the emergence of the ‘energy humanities’, a subfield that examines how cultural artefacts like movies and literary texts reflect on particular sources and uses of energy. Upon closer inspection, however, the field ...
Alternative metals and nanowires for advanced interconnect applications KU Leuven
In the PhD thesis, the electrical, structural, and mechanical properties of thin films and nanowires of alternative metals will be studied. A particular focus will be on the understanding of the scattering mechanisms (surface, grain boundaries) that dominate at small dimensions. Both Pt group metals as well as novel ternary carbides will be studied. I will develop suitable deposition processes for the alternative metals, fabricate nanowires ...
Attenuation correction in Time-of-Flight PET / MRI met additional transmission data Ghent University
In medical imaging is a recent development, the combination of PET and MRI. Nearby MRI anatomical images gives a good contrast in soft tissues, flot PET functional images. PET imaging is based on the principle of radioactive decay by the emission of two photons. If one or both photons are stopped by the patient or their environment before they reach the detector, is called attenuation. Currently, PET combined with CT anatomical images as ...
Dative alternations in Spanish and Portuguese: the case of benefactives and possessives Ghent University
This project contrastively analyzes dative constructions in European Spanish and Portuguese. I will concentrate on cases where the dative represents a possessor (‘LE lavo las manos’ = I wash his hands) or a beneficiary (‘LE hice una tarta’ = I made a cake for him). Possessors and beneficiaries can also be expressed by other constructions (they are said to ‘alternate’, resp. ‘Lavo SUS manos’ with a possessive pronoun and ‘Hice una tarta PARA ...