Publications
Predicting adverse drug events from electronic medical records KU Leuven
Demand-driven clustering in relational domains for predicting adverse drug events KU Leuven
Demand-Driven Clustering in Relational Domains for Predicting Adverse Drug Events. KU Leuven
Anaphylaxis-like reaction to anti-BRAF inhibitor dabrafenib confirmed by drug provocation test Vrije Universiteit Brussel
The combination of BRAF and MEK inhibitors is a standard therapeutic option for patients with metastatic melanoma with BRAF-mutated tumors. This type of targeted therapy improved patient survival, having a manageable toxicity profile. Nevertheless, potentially life-threatening severe toxicity as anaphylaxis-like reactions was observed in two reported cases. No confirmatory testing was performed for these two patients. We report a case of ...
In vitro testing of basal cytotoxicity: establishment of an adverse outcome pathway from chemical insult to cell death Vrije Universiteit Brussel
In this paper, an in vitro basal cytotoxicity testing strategy is described for new chemical entities that lack any pre-existing information on potential toxicity. Special attention is paid to the selection of the cellular system, cytotoxicity assay and exposure conditions. This approach is based on a newly proposed generic adverse outcome pathway from chemical insult to cell death that consists of 3 steps, including initial cell injury, ...
Adverse outcome pathway development from protein alkylation to liver fibrosis Vrije Universiteit Brussel
Incidence and risk factors of serious adverse events during antituberculous treatment in Rwanda: a prospective cohort study Institute of Tropical Medicine
Methodology for computing the burden of disease of adverse events following immunization Institute of Tropical Medicine
Purpose: Composite disease burden measures such as disability-adjusted life-years (DALY) have been widely used to quantify the population-level health impact of disease or injury, but application has been limited for the estimation of the burden of adverse events following immunization. Our objective was to assess the feasibility of adapting the DALY approach for estimating adverse event burden.
Methods: We developed a practical ...