Publications

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The adverse drug reaction risk in older persons (ADRROP) prediction scale : derivation and prospective validation of an ADR risk assessment tool in older multi-morbid patients Ghent University

Denis OU+2019Mahony, Marie Noelle OU+2019Connor, Joseph Eustace, Stephen Byrne, Mirko Petrovic, Paul Gallagher
Background: Adverse drug reactions (ADRs) cause serious morbidity and mortality in multi-morbid older adults. Reliable ADR risk prediction would improve patient safety in this at-risk population. We aimed to derive and validate a new predictive tool for assessing ADR Risk in Older People (acronym ADRROP). Design: We combined four databases describing 2217 older people hospitalized with acute illness in order to determine risk factor variables ...

Development and validation of a risk model for predicting adverse drug reactions in older people during hospital stay : Brighton Adverse Drug Reactions Risk (BADRI) model Ghent University

Balamurugan Tangiisuran, Greg Scutt, Jennifer Stevenson, Juliet Wright, Graziano Onder, Mirko Petrovic, Tischa J van der Cammen, Chakravathi Rajkumar, Graham Davies
Background: Older patients are at an increased risk of developing adverse drug reactions (ADR). Of particular concern are the oldest old, which constitute an increasingly growing population. Having a validated clinical tool to identify those older patients at risk of developing an ADR during hospital stay would enable healthcare staff to put measures in place to reduce the risk of such an event developing. The current study aimed to (1) develop ...

Drug interactions and adverse drug reactions in the older patients admitted to the emergency department Ghent University

Peter De Paepe, Mirko Petrovic, Laurence Outtier, Georges Van Maele, Walter Buylaert
Purpose: The aim of this study was to prospectively evaluate drug interactions and adverse drug reactions (ADRs) in the older patients admitted to the emergency department (ED) and to characterize risk factors. Methods: In 80 patients aged 65 years and older medication history and ED drug administration were-analysed. Medical records were analysed for ADRs by an expert panel which also evaluated their avoidability and causality. An interaction ...

The effect of SENATOR (Software ENgine for the Assessment and optimisation of drug and non-drug Therapy in Older peRsons) on incident adverse drug reactions (ADRs) in an older hospital cohort : trial protocol Ghent University

Amanda H Lavan, Denis OU+2019Mahony, Paul Gallagher, Richard Fordham, Evelyn Flanagan, Darren Dahly, Stephen Byrne, Mirko Petrovic, Adalsteinn Gudmundsson, Olafur Samuelsson, et al.
Background: The aim of this trial is to evaluate the effect of SENATOR software on incident, adverse drug reactions (ADRs) in older, multimorbid, hospitalized patients. The SENATOR software produces a report designed to optimize older patients' current prescriptions by applying the published STOPP and START criteria, highlighting drug-drug and drug-disease interactions and providing non-pharmacological recommendations aimed at reducing the risk ...

Spontaneous reports of adverse drug reactions related to oral anticoagulants in the Czech Republic Vrije Universiteit Brussel

Simona Dvorackova, Katerina Mala-Ladova, Eva Zimcikova, Eva Jirsova, Stephane Steurbaut, Ales Antonin Kubena, Jozef Kolar, Josef Maly

Background Oral anticoagulants are established drugs of choice for the prevention and treatment of thromboembolic events. However, monitoring their safety remains warranted. Objective The aim was to analyze spontaneous reports of adverse drug reactions related to oral anticoagulants in the Czech Republic. Setting Retrospective observational pharmacovigilance study. Methods Adverse drug reaction reports were obtained from the State Institute ...

Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study KU Leuven

Myriam Hanssens
OBJECTIVE: To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. DESIGN: Prospective cohort study. SETTING: 28 hospitals in the Netherlands and Belgium. PARTICIPANTS: 1920 consecutive women treated with tocolytics for threatened preterm labour. MAIN OUTCOME MEASURES: Maternal adverse events (those suspected of being causally related ...

An Artificial Intelligence Approach to Support Detection of Neonatal Adverse Drug Reactions Based on Severity and Probability Scores: A New Risk Score as Web-Tool KU Leuven

Karel Allegaert
BACKGROUND: Critically ill neonates are at greater risk for adverse drug reactions (ADRs). The differentiation of ADRs from reactions associated with organ dysfunction/immaturity or genetic variability is difficult. METHODS: In this prospective cohort study, each ADR was assessed using newborn-specific severity and probability scales by the clinical pharmacist. Subsequently, a machine learning-based risk score was designed to predict ADR ...

Incident adverse drug reactions in geriatric inpatients : a multicentred observational study Ghent University

Amanda Lavan, Joseph Eustace, Darren Dahly, Evelyn Flanagan, Paul Gallagher, Shane Cullinane, Mirko Petrovic, Katrina Perehudoff, Adalsteinn Gudmondsson, Ólafur Samuelsson, et al.
Background: Adverse drug reactions (ADRs) are common in older adults and frequently have serious clinical and economic consequences. This study was conducted as a feasibility study for a randomized control trial (RCT) that will investigate the efficacy of a software engine to optimize medications and reduce incident (in-hospital) ADRs. This study's objectives were to (i) establish current incident ADR rates across the six sites participating in ...

Methotrexate persistence and adverse drug reactions in patients with juvenile idiopathic arthritis Vrije Universiteit Brussel

Lianne Kearsley-Fleet, Laura Vicente González, Douglas Steinke, Rebecca Davies, Diederik De Cock, Eileen Baildam, Michael W Beresford, Helen E Foster, Taunton R Southwood, Wendy Thomson, et al.

OBJECTIVES: This analysis aims to calculate MTX monotherapy persistence and describe the occurrence of and factors associated with the occurrence of adverse drug reactions (ADRs) with MTX.

METHODS: Patients with JIA starting MTX monotherapy from two UK studies were included. Patient characteristics, treatment details and ADR occurrence were collected at treatment start, 6 months, 1 year and annually. The following groups of ADRs were ...