Projects
Prenatal adeno-associated viral transduction of the enteric nervous system as a novel toolbox in neurogastroenterological research. University of Antwerp
Host cell phosphatases in the life cycle of DNA viruses KU Leuven
Back to the future: virus-host interactions guide the development of future gene therapies. KU Leuven
We aim to enhance our understanding of virus-host interactions in the context of AAV replication and apply this knowledge to develop more efficient gene therapy vectors and to increase the efficacy of vector production. Equally, we have drawn inspiration from natural AAV isolates for the engineering of AAV vectors that may be better suited for targeting human tissues than currently available AAV vectors, and have applied these vectors to ...
Development of an ultra-efficient dual AAV gene therapy congenital deafness. KU Leuven
Improving specificity in gene therapy through nanobody coupling of AAV vectors. KU Leuven
Inner ear gene therapy to prevent deafness in DFNA9. University of Antwerp
Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expression KU Leuven
Adeno-associated virus (AAV) is a preferred vector for gene therapy. However, large doses are needed to achieve therapeutic effect. Due to similarities of rAAV gene expression to the latent phase of wild type AAV, where transcription is inhibited, a possible explanation for the low biological bioactivity is gene silencing of the recombinant vector. Several studies show episome formation and chromatization in both wild type and recombinant ...
Genome and transcriptome engineering with CRISPR/Cas as a precision medicine for Charcot-Marie-Tooth type 2L. University of Antwerp
Novel platforms for studying AAV subcellular biology & the design of improved gene therapy vectors KU Leuven
Adeno-associated virus (AAV) gene therapy is currently experiencing a renaissance thanks to a number of successful clinical trials. However, vector doses required to achieve therapeutic effect are high and some tissues remain difficult targets for efficient transduction. In general, gene therapy strategies directed at the brain of patients with inherited neurological or neurodegenerative disorders have shown limited efficacy. One of the main ...