Revealing the molecular mechanisms and adaptive role of aneuploidy plasticity in Leishmania spp Institute of Tropical Medicine
Most eukaryotes have evolved to maintain strict control over the structural transmission of their genomes across several generations. However, in Leishmania, this is not the case. These protozoan parasites have a highly plastic genome characterized by rapid modulation of chromosome copy number, leading to the co-existence of cells with diverging aneuploid karyotypes even in clonal populations. Such modulations in aneuploidy are reflected on ...