Xenotransplantation of iPSC-derived microglia to elucidate the impact of C9orf72 hexanucleotide repeat expansion on neuroinflammation and neurodegeneration. University of Antwerp
A non-coding GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 (C9) gene is the most common genetic cause of frontotemporal dementia (FTD) and associates with Amyotrophic lateral sclerosis (ALS). At present, how this mutation leads to neurodegeneration is unclear. Like other genes linked to FTD, C9 is highly expressed in microglia, suggesting that C9 mutation could lead to microglial dysfunction. This is of particular interest as ...