IP3R dysregulation as a proximal event in Alzheimer’s disease: exploring and exploiting Bcl-2 proteins KU Leuven
Alzheimer’s disease, the most frequent form of dementia, has an enormous impact on quality of life and society. At late stages, the disease is characterized by toxic protein aggregates (amyloid beta) and the demise of cells in the brain (neurons) responsible for memory function. While neuronal loss cannot be reverted and lost neurons cannot replaced, it is possible to delay this process. Thus, it is instrumental to focus on the early stages ...