Analysing the function of APP as Wnt signaling receptor and the relevance for the Alzheimer disease. KU Leuven
Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Research in the
AD field has been mostly focused on the biology of the Ab peptide but increasing evidence is shifting
attention toward the physiological role of APP as key to understanding AD pathology. It is becoming
apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the
robustness of brain wiring. ...