New insights into the fusion process of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages show the way for the development of effective PRRS vaccines Ghent University
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most devastating pathogens in swine. It is genetically unstable and difficult to control by vaccination. Our laboratory has made major contributions to a better understanding of the complex entry of PRRSV into its target cell, the macrophage. PRRSV enters through a receptor-mediated endocytosis and subsequently, a low pH is required to trigger proper viral uncoating. ...