CHICK EMBRYO PLATFORMS FOR PRECLINICAL EVALUATIONS OF PHARMACOLOGICAL EFFECTS: TAKING TUMOR VASCULAR DISRUPTING AGENTS (VDAs) AS EXAMPLES KU Leuven
The aim of the present doctoral thesis was to evaluate pharmacological effects of vascular-disrupting agents (VDAs) in preclinical studies using the chick embryo model. The chick embryo model complies well with the current replace-reduce-refine 3R’s guidelines in animal experiments. It includes biomedical imaging and has demonstrated promising applicability for qualitative and quantitative investigations on pharmaceutical ...