Projects

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Formulation of antigens in immunomodulating microparticles for cancer vaccination Ghent University

Jean Remon
Department of Pharmaceutics

Today cancer remains one of the main causes of death worldwide and it is predicted that the
incidence rate of men and women diagnosed with cancer in their lifespan will increase up to 40
percent. Fortunately, extensive research has dramatically reduced the mortality rate due to
improvement of the existing therapies together with the emergence of new therapeutic
strategies in the immuno-oncology field. As stated in Chapter ...

Vaccination rate in Flanders. KU Leuven

Corinne Vandermeulen
Environment and Health
Vaccines have been the most important medical advance ever and their impact on morbidity and mortality can hardly be overestimated. In addition to individual protection, vaccination programs induce herd immunity resulting in a shielding blanket which is able to give shelter to those who cannot be protected through vaccination because of weak immune response and/or health related contraindication. If the vaccination coverage drops below 90 or 95% ...

Vaccination in individuals/patients and populations at risk KU Leuven

Corinne Vandermeulen
Environment and Health, Laboratory for Clinical Infectious and Inflammatory Disorders

Vaccination does not only provide direct protection against infectious diseases but also contributes to the protection of an entire population when a large proportion of the population is vaccinated and herd immunity is reached. This way vulnerable individuals, namely those who cannot be vaccinated and those who do not respond to vaccination, can also be protected.

My PhD project includes different projects which are related to the ...

Vaccination during pregnancy: unravelling the basic principles. University of Antwerp

Pierre Van Damme
Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO)
Despite the availability of successful universal pertussis vaccination programs, the disease remains an important global public health problem and is nowadays one of the most common vaccinepreventable diseases in the world. The highest incidence and disease burden can be found in infants below one year of age, too young to be completely protected by the currently available vaccines and vaccination schedules. To protect these vulnerable infants, ...

Effect of vaccination against Salmonella Typhimurium in pigs under field conditions Research Institute for Agriculture, Fisheries and Food

Geertrui Rasschaert, Marc Heyndrickx
Food Safety, Technology and Food Science
Main research question/goal
The general aim of the project is to improve the control of Salmonella infections of pigs to deliver scientifically sound advice about the effect of vaccination against Salmonella under field conditions and its eventual implementation in a national control program. The specific objectives are: 1. To investigate to which extent vaccination of sows and/or piglets can play a role in the control of Salmonella ...

A study of the HBsAg specific T-cell and B-cell-mediated immunity in adults, many years after hepatitis B vaccination. University of Antwerp

Koen Van Herck
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Hepatitis B is an infectious disease, which has a global occurrence and which causes substantial morbidity and mortality. Recent estimates show that 1/3 of the world's population has ever been exposed to the hepatitis B virus (HBV), that 367 million people are HBV carriers, and that hepatitis B causes 600,000 deaths each year. Yet hepatitis B is prevenatble by vaccination. Therefore, the World Health Organization (WHO) has incited to incorporate ...

Pertussis vaccination during pregnancy: long term effects in children and pregnant women. University of Antwerp

Kirsten Maertens
Centre for the Evaluation of Vaccination (CEV)
Despite successful universal pertussis vaccination programs, the disease remains an important public health problem and is nowadays still one of the most common vaccine-preventable diseases in the world. The highest incidence and disease burden can be found in infants below one year of age, too young to be completely protected by the available vaccines and vaccinations schedules. To better protect these infants, maternal pertussis vaccination ...

Pertussis vaccination during pregnancy: long term effects on children's immunity before and after administration of a fifth dose of a pertussis containing vaccine. University of Antwerp

Kirsten Maertens
Centre for the Evaluation of Vaccination (CEV)
Despite successful universal pertussis vaccination programs, the disease remains an important public health problem and is still one of the most common vaccine-preventable diseases in the world. The highest incidence and disease burden can be found in infants below one year, too young to be completely protected by the available vaccines and vaccination schedules. To protect these infants,alternative vaccination strategies are needed.During ...

Evaluation of simplified alternative pre-exposure rabies vaccination schedules Institute of Tropical Medicine

Pierre Van Damme, Emmanuel Bottieau
Tropical Medicine, Travel Clinic
Rabies is one of the neglected tropical diseases prioritized by WHO and it is the infectious disease with the highest case-fatality rate. The human death toll is highest in Asia and Africa, with invariably fatal encephalitis in at least 59.000 cases yearly. In literature, pre-exposure intradermal vaccination for rabies has proven to be as effective for pre-exposure and post-exposure prophylaxis as intramuscular vaccination. Intradermal ...