Projects
Insights into the susceptibility to viral infections in ADA2 deficiency KU Leuven
With this project, I aim to understand the origin of increased susceptibility to viral infections in patients with ADA2 deficiency by: assessing the antiviral immunity in ADA2 deficient cell lines (fibroblasts, monocytes) and testing the hypothesis that secreted ADA2 and/or intracellular ADA2 play a role in antiviral defense, either directly or indirectly; studying the susceptibility of keratinocytes to HPV and test the potential rescue ...
ReLACT: Intranasal probiotics against respiratory viral infections. University of Antwerp
Pathogenic processes of viral infections of mammals. University of Antwerp
Viral and cellular factors that determine virus replication and clinical picture during infections with equine arteritisvirus in horse Ghent University
Infections with equine arteritis virus have different clinical outcomes. They are either subclinical, or clinical with only reproductive failure, or clinical with severe clinical signs (oedema, fever, respiraotry problems, colic). The etiology of this different clinical outcome is not known and will be examined in the present project. Special attention will be paid to differences in cell tropism and its basis.
Immuno-ecology of viral infections in the multimammate mouse Mastomys natalensis: characterisation of of class I and class II MHC genes. University of Antwerp
Development of an autonomous (i)SIMPLE patch for the sampling of blood and detection of viral infections KU Leuven
The development of an autonomous microfluidic patch using (i)SIMPLE technology for the sampling of blood using microneedles, and the detection of the Lassa and Ebola virus.
The role of viral infectious triggers in multiple system atrophy KU Leuven
Misfolded protein aggregates appear to be a common feature of several ageing-related neurodegenerative diseases. Parkinson's disease (PD) and Multiple System Atrophy (MSA) belong to the family of synucleinopathies which are characterized by alpha-synuclein protein deposits. Although most studies have focused on the central nervous system, there is increasing evidence that the pathological alpha-synuclein inclusions originate in the periphery, ...
SERIOUS INFECTION IN ACUTELY ILL CHILDREN IN PRIMARY CARE: Validating clinical prediction rules and added value of vital signs and point-of-care tests KU Leuven
Background: Acute infection is the most common presentation of children to ambulatory care. In contrast, serious infections are rare and often present at an early stage. To avoid complications or death, early recognition and adequate referral are essential. In a recent large study children were included prospectively to construct a symptom-based decision tree with a sensitivity and negative predictive value of nearly 100%. To reduce the ...