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Development and validation of a bona fide iPSC derived human neuronal infection model to evaluate antivirals targeted against neurotropic viral infections. University of Antwerp

Peter Delputte
Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Laboratory for Experimental Hematology (LEH), Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Neurotropic viral infections continue to cause major disease and economic burden. Such infections are most commonly caused by herpesviruses, arboviruses and enteroviruses, often leading to severe neurological damage with poor clinical outcomes. The search for interventions to prevent and/or treat these infections is however challenging. The main reason for this is the nature of the target cells, neurons, which are chiefly non-renewable and ...

Valorization of novel strategies for the prevention of viral infection and inhibition of viral replication. KU Leuven

Johan Neyts
Intellectual Property, Laboratory of Virology and Chemotherapy (Rega Institute)

Antiviral drugs are only available for a handful of viruses. Also in the vaccine field a similar scenario can be seen. For many other viral infections that pose an important treat to human health (including re-emerging & neglected infections), there are no antiviral strategies available. The changing ecosystem increases the pressure on the appearance of (novel) viruses (with epidemic/pandemic potential). With this project, we aim to ...

Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chicken Ghent University

Niek Sanders
Department of Pathobiology, Pharmacology and Zoological Medicine, Department of Pharmaceutics, Department of Translational Physiology, Infectiology and Public Health, Department of Veterinary and Biosciences

In this project we will introduce our self-amplifying mRNA vaccine platform in chicken. To that end we will design and in vitro validate two mRNA vaccines encoding selected antigens of one of the most important pathogens in poultry production. Subsequently, we will formulate the sa-mRNA vaccines with UGent owned lipid nanoparticles and investigate their immunogencity and protection efficacy in a challenge study in chicken.

Viral infections: molecular insights, targets for intervention and drug development KU Leuven

Dominique Schols, Jan Balzarini
Centre of Microbial and Plant Genetics, Laboratory of Clinical and Epidemiological Virology (Rega Institute), Laboratory of Virology and Chemotherapy (Rega Institute)
Pathogen (including viral) infections are responsible for a high incif morbidity, mortality and economic losses. Antiviral chemotherapeutics her not available, or have often a limited use due to long-term side effd/or eventual drug resistance development. Within the current thic targets virus entry and transmission are still under-represented. Thenbsp;efforts (including ours) have for a long time been focused on otherle targets such as ...

Peripheral mucin mRNA isoform-based biomarker panels that differentiate bacterial from viral respiratory tract infections. University of Antwerp

Annemieke Smet
Laboratory Experimental Medicine and Pediatrics (LEMP)
Antimicrobial resistance is still one of the most serious global public health threats and is partly due to the inappropriate use of antibiotics. Acute respiratory tract infections (RTIs), affecting the upper respiratory system (e.g. sinusitis, pharyngitis and cold) or the lower part of the respiratory tract (e.g. acute bronchitis and pneumonia), are the main reasons for antibiotic prescription in primary care. Besides causing primary RTIs, ...

A population genomic perspective on persistent viral infections. KU Leuven

Philippe Lemey
Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Viral infections and their associated diseases represent an eminent and worldwide threat to public health. Although viral pathologies are well described, it remains an enormous challenge to intervene with epidemic spread and disease development in the host. A better understanding of the link between diseases, epidemic processes and pathogen evolution, both within and among hosts, is essential in the struggle against viral infections. The goal of ...

Sabbatical Ellen Decaestecker: The role of viral and multiple infections in hostmicrobiome coevolutionary adaptations. KU Leuven

Ellen Decaestecker
Biology, Kulak Kortrijk Campus

The aim is to extend my research expertise from the microbiome and parasite research to multiple infections with a focus on viral infections and their role in co-evolutionary adaptations in order to prepare an ERCadv Grant. Until now, co-evolution has mainly been investigated in the context of simple, microbial infections, while it is clear that viruses can play an important role. One way of doing this is by integrating viral genomes that ...

The interaction between viral infections and the airway microbiome in young cystic fibrosis patients. University of Antwerp

Kim Van Hoorenbeeck
Laboratory of Applied Microbiology and Biotechnology (LAMB), Environmental Ecology & Applied Microbiology (ENdEMIC), Laboratory Experimental Medicine and Pediatrics (LEMP)
Introduction: Most children are diagnosed with cystic fibrosis (CF) at a young age, nowadays often through neonatal screening. CF is associated with frequent respiratory tract infections. These exacerbations are often viral induced at a young age. Frequent airway infections lead to early colonization of the airways with pathogenic bacteria. Moreover, infection leads to inflammation and dysregulation of the mucus production via mucin ...

Unraveling the susceptibility and pathogenesis of viral infections using zebrafish KU Leuven

Peter de Witte
Molecular Biodiscovery, Laboratory of Virology and Chemotherapy (Rega Institute)
Knowledge on the biology and pathogenesis of human viruses has long been hindered by the lack of robust and physiologically relevant culture systems and small animal models. Our team has recently established a robust human norovirus replication model in zebrafish (Danio rerio), a small optically transparent animal, suitable for live imaging and whole-organism pathology. Although noroviruses are the most common cause of foodborne ...