1 - 10 of 102 results
Valorization of novel strategies for the prevention of viral infection and inhibition of viral replication. KU Leuven
Antiviral drugs are only available for a handful of viruses. Also in the vaccine field a similar scenario can be seen. For many other viral infections that pose an important treat to human health (including re-emerging & neglected infections), there are no antiviral strategies available. The changing ecosystem increases the pressure on the appearance of (novel) viruses (with epidemic/pandemic potential). With this project, we aim to ...
Role of viral glycans and siglec receptors for infection of macrophages and viral immune evasion Ghent University
The role of different siglec receptors for viral infection of macrophages and the potential role of siglec-specific virus internatlization for immune evasion will be studied.
Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chicken Ghent University
In this project we will introduce our self-amplifying mRNA vaccine platform in chicken. To that end we will design and in vitro validate two mRNA vaccines encoding selected antigens of one of the most important pathogens in poultry production. Subsequently, we will formulate the sa-mRNA vaccines with UGent owned lipid nanoparticles and investigate their immunogencity and protection efficacy in a challenge study in chicken.
Viral infections: molecular insights, targets for intervention and drug development KU Leuven
A population genomic perspective on persistent viral infections. KU Leuven
Sabbatical Ellen Decaestecker: The role of viral and multiple infections in hostmicrobiome coevolutionary adaptations. KU Leuven
The aim is to extend my research expertise from the microbiome and parasite research to multiple infections with a focus on viral infections and their role in co-evolutionary adaptations in order to prepare an ERCadv Grant. Until now, co-evolution has mainly been investigated in the context of simple, microbial infections, while it is clear that viruses can play an important role. One way of doing this is by integrating viral genomes that ...
Unraveling the susceptibility and pathogenesis of viral infections using zebrafish KU Leuven
ReLACT: Intranasal probiotics against respiratory viral infections. University of Antwerp
Viral and cellular factors that determine virus replication and clinical picture during infections with equine arteritisvirus in horse Ghent University
Infections with equine arteritis virus have different clinical outcomes. They are either subclinical, or clinical with only reproductive failure, or clinical with severe clinical signs (oedema, fever, respiraotry problems, colic). The etiology of this different clinical outcome is not known and will be examined in the present project. Special attention will be paid to differences in cell tropism and its basis.