Projects
Role of autophagy in normal and atherosclerotic arteries University of Antwerp
Role of endothelial autophagy in vascular disease University of Antwerp
ScRNA-seq analysis of tumor endothelial cells and cancer cells to unravel vessel co-option, a resistance mechanism to anti-angiogenic therapy KU Leuven
Endothelial cells (ECs) line the blood vessels and play diverse roles in several biomechanical and biochemical functions such as angiogenesis, regulation of vessel permeability, hemostasis, leukocyte transmigration, vasomotor regulation and immunomodulation. In tumors, sprouting angiogenesis is often considered the most significant mechanism of tumor vascularization and thus became the main target for anti-angiogenic therapy (AAT). During ...
Role of autophagy in the cardiovascular system. University of Antwerp
Role of autophagy in the cardiovascular system. University of Antwerp
Role of autophagy in the cardiovascular system. University of Antwerp
Understanding brain circuit dysfunction in amblyopia using large-scale multimodal recordings in a new visuomotor task applied to animal models and patients KU Leuven
We aim to establish the role of predictive processing in neurodevelopmental disorders, specifically in one of the most studied contexts, amblyopia. We use a new visuomotor feedback task across high-visual-acuity preclinical species - cats -, rodents, and humans during large-scale activity readout via best-available methods (functional ultrasound imaging reaching 4 cm depth, mesoscale two-photon imaging, hdEEG) to 1) identify brain regions ...
BRAINSHAPE: Objects in sight: the neural basis of visuomotor transformations for actions towards objects. KU Leuven
Neural Mechanisms Underlying Blindsight in Monkeys KU Leuven
After damage to the primary visual cortex (V1) the patients experiences clinical blindness in the corresponding part of the visual field. Nevertheless, several visuo-motor functions persist due to the functionality of multiple V1-independent pathways. Recent evidence suggest that brain plasticity can be promoted through training and/or stimulation to promote partial recovery of visual functions. The present project investigates the neural ...