Projects
The potential of Lactobacillus exopolysaccharides and glycoproteins as safe vaccine adjuvants. University of Antwerp
LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cells Ghent University
This project aims to put UGent at the forefront of mRNA-vaccine research by providing in-depth insights in the adjuvant properties of LNP-based mRNA-vaccines. To this end, we will join the expertise of 3 teams working on dendritic cell biology, nucleic acid sensors and lipid nanoparticles respectively.This consortium will form the basis for the development of vaccines against autoimmune diseases.
The working mechanism of a new class of adjuvant, the Layered Double Hydroxide (LDH) family. Ghent University
This interdisciplinary project combines key aspects of chemistry and immunology to predict which members of a new class of adjuvants, the Layered double hydroxide family (LDH), induce a better cellular and/or humoral immune response than the common used adjuvant alum. Besides, we will unravel their cellular and molecular mechanism of action and their applicability in an influenza infection model.
A novel, DNA-based, live-attenuated vaccine for the yellow fever virus and other medically important flaviviruses. KU Leuven
Many vaccines are still composed of a purified antigen or a whole, inactivated pathogen combined with adjuvants. Alternatively, as is the case for yellow fever virus (YFV), measles, mumps and rubella, purified, live-attenuated virus vaccines are available. Both types of vaccines are expensive to produce and require a cold distribution chain from manufacturer to patient, which is in particular hard to achieve in resource-poor or remote ...
Dendritic cells as a potential target for the development of an atherosclerosis vaccine. University of Antwerp
Polymer-lipid amphiphile carriers for small molecule immune-modulators Ghent University
The aim of this Concept TT is to obtain a technical proof of concept that shows the potential of polymer-lipid amphiphiles as carrier for lymph node-targeted delivery of small molecule immuno-modulators. Ultimately, the research results will be used to support a patent application.
Adjuvanting aminopeptidase N-targeted oral vaccines to protect against gut pathogens Ghent University
Aminopeptidase N-mediated delivery of vaccine antigens to the gut immune system holds great promise to develop efficacious oral vaccines to combat gut pathogens in pigs. This project builds further on previous data showing protective immunity against infection with pathogenic E. coli induced by oral vaccination of piglets with aminopeptidase N-targeted vaccine antigens. In this project, we aim to optimize the design of our aminopeptidase ...