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Improving (cost-) effectiveness analyses of rotavirus vaccination programmes: combining dynamic modelling with in-depth uncertainty analysis. University of Antwerp

Philippe Beutels
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Research objectives General research objective - To advance the field of health economics of vaccines with respectto transmission-dynamic modelling and uncertainty analysis. This will be done by applying the most advanced techniques within these two key-areas to the real-world example of rotavirus disease and vaccination.Specific research objective - In particular, the proposed project aims to develop a model which best represents current ...

A study of the HBsAg specific T-cell and B-cell-mediated immunity in adults, many years after hepatitis B vaccination. University of Antwerp

Koen Van Herck
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Hepatitis B is an infectious disease, which has a global occurrence and which causes substantial morbidity and mortality. Recent estimates show that 1/3 of the world's population has ever been exposed to the hepatitis B virus (HBV), that 367 million people are HBV carriers, and that hepatitis B causes 600,000 deaths each year. Yet hepatitis B is prevenatble by vaccination. Therefore, the World Health Organization (WHO) has incited to incorporate ...

Pertussis vaccination during pregnancy: long term effects on children's immunity before and after administration of a fifth dose of a pertussis containing vaccine. University of Antwerp

Kirsten Maertens
Centre for the Evaluation of Vaccination (CEV)
Despite successful universal pertussis vaccination programs, the disease remains an important public health problem and is still one of the most common vaccine-preventable diseases in the world. The highest incidence and disease burden can be found in infants below one year, too young to be completely protected by the available vaccines and vaccination schedules. To protect these infants,alternative vaccination strategies are needed.During ...

The historical impact of vaccination. University of Antwerp

Philippe Beutels
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Vaccines are among the most effective public health tools for the prevention and control of infectious diseases, but public confidence in vaccination programs is decreasing. Scientific evidence on the historical impact of vaccination programs can be used for scientific research and advocacy. As main part of this project, a workshop is to be held at UAntwerpen on the historical impact of vaccination, attended by 30 participants from 10 European ...

Acceptability of conventional screening through gynaecological examination and of vaccination as preventive measures for cervical cancer Ghent University

Marleen Temmerman
Department of Uro-gynaecology

Cervical cancer, caused by the human papillomavirus (HPV), is responsable for almost 500,000.00 deaths a year most victims live in Sub-Saharan Africa. With the invention of the HPV vaccine, primary prevention became possible, next to secondary prevention techniques. Before implementing large-scale vaccination programmes however, acceptability of the vaccine by the target group needs to be assessed to guarantee high coverage.

Research Agreement for the WHO-project: " Influenza illness and vaccination in Asia: Data collection of Social Contacts and Mixing Patterns" Hasselt University

Niel HENS
Centre for Statistics
Infectious diseases such as influenza can be spread when individuals come into close contact with each other. Better knowledge of these contact patterns will facilitate a greater understanding of influenza transmission. This knowledge will help produce better predictive models of the spread of influenza, leading to improved estimates of the effectiveness and cost-effectiveness of alternative control programmes. Diary-based approaches have ...

Streptococcus pneumoniae in conjugate vaccine period: epidemiology and molecular characterization KU Leuven

Laboratory of Clinical Microbiology, Laboratory of Clinical and Epidemiological Virology (Rega Institute)

Vaccination of young children with pneumococcal conjugate vaccines is an important
tool to decrease the burden of pneumococcal disease.
In the first chapter we investigated the evolution of invasive pneumococcal disease
in Belgium during the sequential use of different pneumococcal conjugate vaccines
(2007-2018) with a focus on the period aft er the switch from PCV13 to PCV10 (2016-
2018). During the study ...

Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa? Ghent University

Sarah Gabriël
Department of Translational Physiology, Infectiology and Public Health, Department of Veterinary Public Health and Food Safety

Taenia solium taeniosis/cysticercosis is a neglected zoonotic parasitic disease complex with significant economic and public health impacts, occurring primarily in developing countries. Humans are the carriers of the tapeworm (taeniosis); the normal intermediate pig host develops the metacestode larval stage (porcine cysticercosis). However, people can also act as accidental intermediate hosts and develop human cysticercosis or ...

Polyclonal B-cell activation in human African tryponosomiasis (HAT): impact on acquired immunity and on rapid diagnostic tests. Institute of Tropical Medicine

Philippe Büscher
Programme National de Lutte contre la Trypanosomiase Humaine, Programme de Lutte contre le Sida, National Institute of Biomedical Research, PEV RD Congo, Programme National de Lutte contre le Paludisme, Tropical Medicine, Tropical Bacteriology, Neglected Tropical Diseases, HIV and Tuberculosis, Diagnostic Parasitology



Mouse-models help to understand host-pathogen
immune interactions and serve as model for vaccine development in human African
trypanosomiasis (HAT) but their validity for what happens in man remains
largely unknown. A better understanding of the immune deregulation observed in
HAT, especially related to the B-cell compartment, is therefore needed and may
have implications on clinical management and control of other ...

Assessment of the nasopharyngeal carriage of Streptococcus pneumoniae and other common pathogens in infants (6-30 months) with acute otitis media and in healthy infants (6-30 months) attending day-care centres in Belgium. University of Antwerp

Pierre Van Damme
Vaccine & Infectious Disease Institute (VAXINFECTIO)
General use of vaccines against Streptococcus pneumoniae (S. pneumoniae) in infants has led to a decrease in the presence of the serotypes against which the vaccine was developed. It is a pathogen of which more than 90 different serotypes exist, of whom 10 to 13 are covered by the current vaccines. In order to gain a clear understanding of the S. pneumoniae serotypes carried by infants, and the impact of the vaccine used in the vaccination ...