Keys to unlock ATP13A2, a novel P-type transport ATPase implicated in Parkinsons disease. KU Leuven
The major aim of the project is to gain novel insights in the cell biological and pathological role of ATP13A2.
The major aim of the project is to gain novel insights in the cell biological and pathological role of ATP13A2.
ATP13A2 (also called PARK9), is a transmembrane endo-/lysosomal-associated P5-type transport ATPase. Loss-of-function mutations in ATP13A2 result in the Kufor-Rakeb Syndrome (KRS), a form of autosomal Parkinson’s disease (PD). In spite of a growing interest in ATP13A2, very little is known about its physiological role in stressed cells. Recent studies suggest that the N terminal domain of ATP13A2 may hold key regulatory functions, but their ...
The interest in ageing research not only stems from an intrinsic curiosity towards the matter, but also from the fact that the incidence of several diseases increase exponentially with age. The examples of such age-related disorders are ample and include multiple cancers and neurodegenerative disorders including Alzheimer’s and Parkinson’s disease. As such, a lot of research has been performed to unravel the mysteries of ageing. The budding ...
Insects are among the most successful organisms on the planet. One explanation for their success is their extraordinary ability to successfully consume a wide range of foods. Like all heterotrophic organisms, insects need to acquire vital nutrients from their diet. The central organ for food digestion and absorption of nutrients is the gastrointestinal tract. This organ’s principal functions are to mediate the efficient digestion of food and ...
Cells of all living organisms are equipped with complex signal transduction networks enabling to make appropriate changes in metabolism in response to environmental changes. In this project, our focus is on how several signaling pathways in brewer’s yeast and pathogenic fungi integrate to control traits like stress resistance, reserve carbohydrate metabolism, lipid metabolism, ageing and lifespan, drug tolerance and, in case of pathogenic ...
Cells have developed a sophisticated sensing and signaling system to adapt and survive in response to a variety of environmental challenges, such as temperature, pH, osmotic pressure, and nutrient availability. As in other eukaryotes, yeast cells employ a complex Ca2+ signaling network to regulate diverse cellular processes upon external stimuli. Several lines of evidence indicate that the glucose-induced activation of plasma membrane ...