The role of the unfolded protein response in radiation-induced anti-tumor responses Ghent University
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are believed to be involved in the regulation of immunogenic cell death in cancer cells following high-dose radiation therapy (RT)(1,2). In addition, recent evidence from our group suggests that the IRE-1a/XBP-1 branch of the UPR plays a crucial role in the antigen presentation of dead cells by CD8A+ dendritic cells (DCs)(3). In this project, we therefore hypothesize ...