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ULTIMO: Piezoelectric micromachined ultrasound transducers (pMUT) for the next generation of low-cost, portable and high-performance medical ultrasound imaging probes (Ultrasound Imaging on Mobile) KU Leuven

Michael Kraft
Micro- and Nano Systems (MNS), Electronic Circuits and Systems (ECS)
The ULTIMO project presents a handheld ultrasound device with a large aperture for medical imaging applications. A large aperture transducer array leads to a significantly increased resolution and penetration depth. To achieve this, we will further develop our piezoelectric micromachined ultrasound transducer (pMUT) technology towards a first prototype. This type of transducer answers the requirements of various applications in which not only ...

Beam steering and control of large area ultrasound actuator arrays for haptic perception KU Leuven

Paul Heremans
ESAT - MICAS, Microelectronics and Sensors

Traditional microphone units focus on human perceptible sound waves (between 20 Hz and 20 kHz). Acoustic development also focuses on ultrasound, compromising the frequencies above the detection limit of the human ear (from 20 kHz to several GHz). These sound waves can be used for a wide variety of applications, including medical imaging, therapeutic treatment, non-destructive testing and position localization of objects. Nowadays, ultrasonic ...

Ultrasound assisted crystallisation in microreactors KU Leuven

Leen Braeken, Tom Van Gerven
Sustainable Chemical Process Technology, Diepenbeek Campus, Process Engineering for Sustainable Systems Section

This research project studied the use of ultrasound in cooling crystallization as an alternative seeding and particle engineering technique. To accomplish this goal, the fundamentals of the cavitation phenomena were first studied to identify the operating conditions suitable for crystallization. Next, the implementation, operation and settings of the ultrasonic field during cooling crystallization were optimized. Finally, possible reactor ...

Mechanical high intensity focused ultrasound (mHIFU): exploring the synergistic effects between killing tumor cells and inducing antitumor immunity in vivo. Ghent University

Department of Pharmaceutics

The discovery that certain types of “classical” cancer therapies, including specific chemotherapeutic
drugs and radiotherapy regimens were able to kill tumor cells in such a way that they alert the
patient’s immune response, revolutionized our view on the interaction of these therapies with the
immune system. This so-called immunogenic cell death (ICD) brings about an army of immune cells
that can specifically ...

Experimentally validated computational pipeline of ultrasound propagation and neuron-coupling for non-invasive peripheral nervous system stimulation Ghent University

Emmeric Tanghe
Department of Information technology, École Polytechnique Fédérale de Lausanne, Foundation for Research on Information Technologies in Society

Ultrasound has gained attention in the last decade for the application of high-precision non-invasive neuromodulation. In particular, ultrasound can reach deep targets with millimeter precision and without surgery, in contrast to existing electrostimulation technologies. However, limited understanding of the mechanism by which ultrasound interacts with neurons has hampered systematic neural engineering studies, that aim to design ultrasound ...

Large Area Ultrasound Actuator Arrays for Haptic Perception KU Leuven

Paul Heremans
Electronic Circuits and Systems (ECS)

Traditional microphone units focus on human perceptible sound waves (between 20 Hz and 20 kHz). Acoustic development also focuses on ultrasound, compromising the frequencies above the detection limit of the human ear (from 20 kHz to several GHz). These sound waves can be used for a wide variety of applications, including medical imaging, therapeutic treatment, non-destructive testing and position localization of objects. Nowadays, ultrasonic ...

Wireless Powering of Brain Implants with Ultrasound KU Leuven

Chris Van Hoof
Electronic Circuits and Systems (ECS)
The miniaturization revolution that we see in communication and computing is also occurring in the medical diagnostic and therapeutic world. In recent years there has been a rapid emergence of advanced (wearable) medical devices that bring high quality medically relevant diagnostics in an increasingly convenient format at ever lower costs. More recently, there has been a shift toward advanced implantable devices that require minimally invasive ...

Investigating the neuromodulatory effect of focused ultrasound in the human brain. Ghent University

Kristl Vonck
Department of Head and Skin

Brain disorders affect one in four people and treatment is often ineffective or invasive. It is an aspiration of medicine and neuroscience to non-invasively modulate any given region of the brain with high precision. Ultrasonic waves can be safely focused through the human skull and are able to modulate neuronal activity at millimeter resolution. The currently available ultrasonic
neuromodulation protocols for human applications have ...

Reconstruction of acoustic tissue properties for ultrasound tissue characterization KU Leuven

Jan D'hooge
Physics, Kulak Kortrijk Campus, Cardiovascular Imaging and Dynamics

Ultrasound imaging is an indispensable tool in medical diagnostics and offers several advantages over other imaging techniques. During last decades, ultrasound technology has achieved significant progress leading to improved image quality. However, conventional ultrasound envelope-detected images remain qualitative in nature and lack quantitative information on the tissue state and pathology. Therefore, there has been an increased interest in ...

Functional and dynamic assessment of knee ligament balancing based on 3D ultrasound imaging KU Leuven

Lennart Scheys
Locomotor and Neurological Disorders

Total knee arthroplasty (TKA) is a very common intervention to relieve pain and restore function in case of knee osteoarthritis. A major determinant for good (long-term) outcome of this intervention is a robust assessment of the biomechanical properties of the soft tissue surrounding the joint. Unfortunately, assessment of these properties is currently only possible through indirect measurements, in addition to being invasive and only ...