Neutrophils and post-translationally modified beta-cell proteins: a driving force behind type 1 diabetes? KU Leuven
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the selective destruction of the pancreatic insulin-producing beta cells by infiltrating immune cells, leading to an absolute insulin deficiency. The prevalence of T1D is increasing worldwide and the concern regarding the number of new T1D cases relates in part to the development of chronic complications, either microvascular (i.e., retinopathy, neuropathy, and ...