MACYCs / Membrane Anchoring CYtokine ChimeraS: Unlocking the full potential of tumor acidity for tumor-targeted cytokine delivery. Ghent University
Immunotherapy, including checkpoint inhibitors and CAR-T cell therapy, has revolutionized oncology. While these mount durable antitumor responses in some patients, the overall response rate remains modest. Hence, an unmet medical need exists to increase the overall efficacy of immunotherapy. Cytokines, including IL-2 and IL-12, can achieve this. However, poor pharmacokinetics and systemic toxicities hamper clinical translation. The current ...