Novel High-Dose Tuberculosis Retreatment Regimens: How to overcome resistance without creating more? Institute of Tropical Medicine
Globally, Tuberculosis (TB) is a leading cause of death from infectious cause. Drug-resistance to the most powerful drugs, rifampicin and isoniazid, hampers TB control. Those with resistance to rifampicin need multidrug resistant TB treatment, but evidence is lacking for how to best treat recurrent TB resistant to isoniazid but not rifampicin. For decennia a longer streptomycin strengthened regimen (Cat.2) was used to overcome ...