Publications
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Rapid diagnosis of rifampicin resistance: who needs confirmation? [editorial] Institute of Tropical Medicine
1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors Ghent University University of Antwerp
A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modifications of the scaffold of 3 failed to afford substantial improvements in MtbTMPK inhibitory activity and antimycobacterial activity. Optimization of the substitution pattern of the D ring of 3 ...
Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS Institute of Tropical Medicine University of Antwerp
BACKGROUND: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) remains a poorly understood complication in HIV-TB patients receiving antiretroviral therapy (ART). TB-IRIS could be associated with an exaggerated immune response to TB-antigens. We compared the recovery of IFNγ responses to recall and TB-antigens and explored in vitro innate cytokine production in TB-IRIS patients.
METHODS: In a prospective ...
Skewing of the CD4+ T cell pool towards mono-functional antigen-specific responses in patients with immune reconstitution inflammatory syndrome in The Gambia Institute of Tropical Medicine
Background. A common complication of starting anti-retroviral therapy (ART) for HIV is the development of Immune Reconstitution Inflammatory Syndrome (IRIS) in approximately 25% of patients. Despite similarities with paradoxical reactions to tuberculosis and reversal reactions in leprosy, the exact mechanisms, and therefore potential determinants, of IRIS are still unknown. Methods. In this longitudinal cohort study, we analysed 20 patients who ...
Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents Ghent University University of Antwerp
Nontuberculous mycobacterial disease in patients with HIV in Southeast Asia Institute of Tropical Medicine
Burden and outcome of HIV infection and other morbidities in health care workers attending an Occupational Health Program at the Provincial Hospital of Tete, Mozambique Institute of Tropical Medicine
Objectives To investigate the burden and outcome of HIV infection and other morbidities amongst a Mozambican hospital staff. Methods Within an occupational health service set up in April 2008 in the provincial hospital of Tete, Mozambique, we offered to all staff members an initial clinical, laboratory and radiological screening and followed them up prospectively until April 2010. Results A total of 47.5% of 423 health workers attended the ...
Operational assessment of access to ART in rural Africa: the example of Kisantu in Democratic Republic of the Congo Institute of Tropical Medicine
Despite the availability of large funds and considerable efforts to improve access to antiretroviral therapy (ART), coverage of treatment with ART remains low in Democratic Republic of the Congo (DRC). We identified the bottlenecks for adults' access to ART in a semi-rural health zone in DRC, compared ART coverage in the urban and rural area and described the outcomes and yield of different HIV testing settings. An operational model was used to ...
Incidence and risk factors of serious adverse events during antituberculous treatment in Rwanda: a prospective cohort study Institute of Tropical Medicine
BACKGROUND: Tuberculosis (TB) and TB-human immunodeficiency virus infection (HIV) coinfection is a major public health concern in resource-limited settings. Although TB treatment is challenging in HIV-infected patients because of treatment interactions, immunopathological reactions, and concurrent infections, few prospective studies have addressed this in sub-Saharan Africa. In this study we aimed to determine incidence, causes of, and risk ...