Characterization and exploitation of the mycothiol redox system of Mycobacterium tuberculosis Vrije Universiteit Brussel
Tuberculosis (TB), once referred to as the ''white death'', is a debilitating human disease caused by Mycobacterium tuberculosis (Mtb). Every 20 seconds a person dies from TB, which sums up to over 2 million deaths each year. Mtb lives and survives in macrophages, which generate antimicrobial radicals such as reactive oxygen species and reactive nitrogen species. As a successful intracellular pathogen, Mtb has evolved with powerful defense ...