Synthesis of potential inhibitors in "mycolocterium tuberculosis" KU Leuven
Mycobacterium tuberculosis, the causative agent of tuberculosis, depends on the biosynthesis of 2-deoxythymidine-5-monophosphate (dTMP) for cellular replication. Until recently, the only known pathway for de novo synthesis of thymidylate was by thymidylate synthase ThyA. However, comparative genomics has demonstrated the existence of two major pathways for dTMP formation in Mycobacterium tuberculosis. ThyX is a flavin-dependent thymidylate ...