Projects
Consequences of Mycobacterium tuberculosis genetic diversity in the context of HIV co-infection for laboratory diagnosis of tuberculosis in Africa Institute of Tropical Medicine
1. To determine the variation and risk factors for drug-resistant tuberculosis in sub-Saharan Africa.
2. To evaluate the clinical utility of a novel molecular assay in various combinations with existing methods for diagnosis of HIV-related tuberculosis.
3. To determine the clinical predictors of mycobacteremia among HIV-infected smear- negative adults in a high prevalence HIV/TB setting in relation to the utility of ...
Studies on multidrug resistance tuberculosis in Rwanda: Turning off the tap Institute of Tropical Medicine
In this PhD proposal, we intend to document the impact of PMDT interventions on the diagnostic- and treatment delays, and the resulting genotypic clustering of MDR-TB over a ...
Development of molecular diagnostic capabilities for the management of multidrug-resistant tuberculosis South Kivu Ghent University
There are no known data regarding the prevalence and incidence of multidrug-resistant tuberculosis in the eastern Democratic Republic of Congo, which are necessary for the development and implementation of a national program to combat the epidemic. Through this project, diagnostic skills are developed to start a monitoring program in both North and South Kivu through advanced molecular biology (PCR).
Innovate to reduce rifampicin-resistant tuberculosis in Rwanda and beyond Institute of Tropical Medicine
Integrated Bovine Tuberculosis Diagnostics Approach: Bio-inspired Approaches KU Leuven
The overarching research question:
"Can we generate a proof-of-concept for improved diagnostics based on naturally prevalent biomolecules?"
More specifically, we will answer the following questions in:
WP2: "Can the heavy chain only antibodies directed against BTB in Alpacas be used as an affinity isolation/detection tool in BTB diagnostics?"
WP3: "Can the cell wall binding domains of endolysins isolated from ...
Molecular Epidemiology of tuberculosis at Human-Animal interface in the pastoral areas of Ethiopia with subsequent development of improved diagnostic approach KU Leuven
Against the available diagnosis and treatment advances, tuberculosis remains a relentless disease that is one of the leading causes of death from a single infectious agent worldwide. More importantly, the highest burden of tuberculosis is attributed to low- and middle-income countries such as Ethiopia, where limited resources and high population density intersect. Since zoonotic mycobacteria have numerous host ranges that serve as ...