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Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals Vrije Universiteit Brussel University of Antwerp KU Leuven Hasselt University

Patrick De Boever, Britt Wens, Anyiawung Chiara Forcheh, Hans Reynders, Vera Nelen, Jos Kleinjans, Nicolas Van Larebeke-Arschodt, Geert Verbeke, Dirk Valkenborg, Greet Schoeters, et al.

A repeated measures microarray design with 22 healthy, non-smoking volunteers (aging 32. ±. 5. years) was set up to study transcriptome profiles in whole blood samples. The results indicate that repeatable data can be obtained with high within-subject correlation. Probes that could discriminate between individuals are associated with immune and inflammatory functions. When investigating possible time trends in the microarray data, we have ...

Alteration in the Culex pipiens transcriptome reveals diverse mechanisms of the mosquito immune system implicated upon Rift Valley fever phlebovirus exposure Institute of Tropical Medicine

Ana I Núñez, Anna Esteve-Codina, Jèssica Gómez-Garrido, Marco Brustolin, Sandra Gómez-Talavera, Miguel Berdugo, Marc Dabad, Tyler Alioto, Albert Bensaid, Núria Busquets, et al.

Rift Valley fever phlebovirus (RVFV) causes an emerging zoonotic disease and is mainly transmitted by Culex and Aedes mosquitoes. While Aedes aegypti-dengue virus (DENV) is the most studied model, less is known about the genes involved in infection-responses in other mosquito-arboviruses pairing. The main objective was to investigate the molecular responses of Cx. pipiens to RVFV exposure focusing mainly on genes implicated in innate immune ...

A praziquantel treatment study of immune and transcriptome profiles in Schistosoma haematobium-infected Gabonese schoolchildren Institute of Tropical Medicine

Lucja A Labuda, Ayola A Adegnika, Bruce A. Rosa, John Martin, Ulysse Ateba-Ngoa, Abena Serwaa Amoah, Honorine Mbenkep Lima, Lynn Meurs, Moustapha Mbow, Mikhael D. Manurung, et al.

Background. Although Schistosoma haematobium infection has been reported to be associated with alterations in immune function, in particular immune hyporesponsiveness, there have been only few studies that have used the approach of removing infection by drug treatment to establish this and to understand the underlying molecular mechanisms.

Methods. Schistosoma haematobium-infected schoolchildren were studied before and after ...

A Co-expression Analysis of the Placental Transcriptome in Association With Maternal Pre-pregnancy BMI and Newborn Birth Weight Hasselt University KU Leuven

Bianca COX, Maria TSAMOU, Karen VRIJENS, Kristof NEVEN, Ellen WINCKELMANS, Theo DE KOK, Michelle PLUSQUIN, Tim NAWROT
Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and later-life health of the newborn, yet the implicated molecular mechanisms remain largely unknown. As the master regulator of the fetal environment, the placenta is a valuable resource for the investigation of processes involved in the developmental programming of metabolic health. We conducted a genome-wide placental transcriptome study aiming at the ...

Molecular diversity of the telson and venom components from Pandinus cavimanus (Scorpionidae Latreille 1802): Transcriptome, venomics and function Hasselt University KU Leuven

Elia Diego-Garcia, Steve Peigneur, Tessa Marien, Lene Czech, Liliane Schoofs, Jan Tytgat
Venom from the scorpion Pandinus cavimanus was obtained by electrical stimulation of the telson (stinger). Total venom was toxic to crickets at 730 mu g and a paralysis or lethal effect was observed at 30 mu g of venom (death at 1.5 mu g/mg of cricket). Electrophysiological analyses showed cytolytic activity of total venom on oocytes at 7 mu g. HPLC allowed separation of the venom components. A total of 38 fractions from total venom were tested ...

Transcriptome analysis of monocytes and macrophages in mycobacterial infection and chronic kidney disease Ghent University

Erica Houthuys
Tissue macrophages and their circulating counterpart, the monocytes, constitute a key component of the innate immune system. Different triggers evoke different macrophage responses leading to different states of macrophage activation. The activation states of the following in vivo elicited macrophages were characterized by transcriptome profiling: (i) granuloma macrophages from mice after infection with Mycobacterium bovis BCG, and (ii) ...

Transcriptome analysis of neuropeptides in the beneficial insect lacewing (Chrysoperla carnea) identifies kinins as a selective pesticide target : a biostable kinin analogue with activity against the peach potato aphid Myzus persicae Ghent University

Shi Yan, Aniruddha Pandit, Ronald J. Nachman, Olivier Christiaens, Shireen A. Davies, Julian A. T. Dow, Guy Smagghe
The common green lacewing Chrysoperla carnea (Neuroptera), also called the aphid lion, is an important predator of pest species, especially aphids that cause serious damage in many crops in agriculture. Neuropeptides are involved in regulating various physiological processes in insects. However, there have not been many studies on the neuropeptides found in C. carnea. This study aimed to assemble and define a whole body- and head-specific ...

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis Vrije Universiteit Brussel

Hang Thi Thu Nguyen, Robin B Guevarra, Stefan Magez, Magdalena Radwanska

Salivarian trypanosomes are extracellular protozoan parasites causing infections in a wide range of mammalian hosts, with Trypanosoma evansi having the widest geographic distribution, reaching territories far outside Africa and occasionally even Europe. Besides causing the animal diseases, T. evansi can cause atypical Human Trypanosomosis. The success of this parasite is attributed to its capacity to evade and disable the mammalian defense ...

Stromal contribution to the colorectal cancer transcriptome Vrije Universiteit Brussel

Claudio Isella, Andrea Terrasi, Sara Erika Bellomo, Consalvo Petti, Giovanni Galatola, Andrea Muratore, Alfredo Mellano, Rebecca Senetta, Adele Cassenti, Cristina Sonetto, et al.

Recent studies identified a poor-prognosis stem/serrated/mesenchymal (SSM) transcriptional subtype of colorectal cancer (CRC). We noted that genes upregulated in this subtype are also prominently expressed by stromal cells, suggesting that SSM transcripts could derive from stromal rather than epithelial cancer cells. To test this hypothesis, we analyzed CRC expression data from patient-derived xenografts, where mouse stroma supports human ...

Mesoderm-derived stem cells: the link between the transcriptome and their differentiation potential. Vrije Universiteit Brussel

Jennifer Bolleyn, Feras Albattah, Gordana Raicevic, Olivier Govaere, Steven Branson, Kesavan Meganathan, John Antonydas Gaspar, Agapios Sachinidis
Human multipotent adult stem cells (hASCs) have become an attractive source for autologous cell transplantation, tissue engineering, developmental biology and the generation of human-based alternative in vitro models. Among the three germ cell layers, the mesoderm is the origin of today's most widely used and characterized hASC populations. A variety of isolated non-hematopoietic mesoderm-derived stem cell populations exists and all of them show ...