Projects
How successfully do older Europeans age?A new measurement toolbox and its application with data from SHARE. University of Antwerp
Development of a user-friendly virtual material characterization toolbox KU Leuven
GEAR PREDICT A generic toolbox for the reliable prediction of lifetime and ageing in electrochemical systems Vrije Universiteit Brussel
Industrial computer vision services enabled by a generic Python camera toolbox. University of Antwerp
Development of a laboratory toolbox to study human circular RNAs Ghent University
Circular RNAs (circRNAs) are a novel class of mainly non-coding RNA molecules and have been proposed as promising biomarkers based on their substantially longer half-live compared to other RNA types and their cell-type specific expression patterns. Unfortunately, current circRNA detection pipelines (using RNA-sequencing data) are prone to false positives. As these results propagate to circRNA databases, we are far from a gold standard ...
Tackling functionality and balanced expression of cytochrome P450 enzymes: a generic toolbox for the production of specialized plant metabolites in bacteria Ghent University
The natural diversity of plant metabolites, such as flavonoids, offers a plethora of attractive attributes through the decoration of a common skeleton. Oxygenation is the most commondecoration and is added in the final biochemical steps in the plant endoplasmic reticulum. Industrial production of these specialized flavonoids can be achieved chemically, through plant cell cultures or via extraction. These routes are paired with high costs and ...
Measuring arterial stiffness at different scales: a new toolbox for safety pharmacology. University of Antwerp
Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma. Ghent University
HDAC6 is an enzyme with a wide variety of substrates and interaction partners, which makes it an important regulator of diverse cellular processes and, in case of aberrant function, an actor in several diseases including cancer, neurodegenerative disorders and inflammation. Therefore, inhibitors have been developed to selectively target HDAC6. However, these compounds only target the deacetylase catalytic cavity, while also a ubiquitin ...