Projects
The function of LRRC32 in thrombosis, haemostasis and regulatory T cell homeostasis KU Leuven
Defects in blood platelet receptors often give rise to severe pathologies such as myocardial infarction or bleeding disorders. Therefore, significant efforts are put in the identification of new platelet receptors, with the Leucine Rich Repeat-Containing protein 32 (LRRC32) recently emerging. Next, the function of these receptors has in platelet physiology and thrombosis to be identified and their potential as predictive marker and as target ...
Mechanical Circulatory Support in critically ill cardiogenic shock patients: a complex process of Thrombosis and Hemostasis. KU Leuven
The success of mechanical circulatory support (MCS) has greatly
increased due to improved oxygenators, better design of the heart
pumps and certainly due to better medical management.
Nevertheless mortality of patients undergoing MCS remains high
(50%) and complications are frequent. Paradoxically, the most
common complications are both (life-threatening) bleeding (40-50%)
ánd thrombosis as recently confirmed in ...
Investigating the interplay between von Willebrand factor, platelets, and neutrophil extracellular traps in pathologies involving thrombosis of the microvasculature KU Leuven
White blood cells are essential for fighting infection using specific killing mechanisms. However, when these processes get activated in the absence of infection, this can cause disease. Similarly, von Willebrand factor (VWF), which serves as a sort of glue during blood clotting by sticking platelets (small blood cells) to damaged blood vessels, can also lead to disease when it gets released without injury. One of the ways that white blood ...
Specific contribution of transgene plasma and platelet von Willebrand factor in haemostasis and thrombosis: from functional studies to gene therapy. KU Leuven
Ageing and obesity in thrombosis: oxidative stress-induced changes in the vascular wall and blood circulation. KU Leuven
Carboxypeptidase U: a metallocarboxypeptidase with a distinct role in haemostasis and a possible risk factor for thrombotic disease. University of Antwerp
Properties and roles of anti-FVIII inhibitor antibodies in bleeding disorders and thrombose. KU Leuven
Towards Improved Thrombolysis in Acute Ischemic Stroke: an Interdisciplinary Approach Combining Computer Systems Biology With Novel Therapeutic Targets KU Leuven
Ischemic stroke is a devastating disease, representing one of the leading causes of death and disability worldwide. Occlusion of a major or multiple smaller intracerebral arteries by blood thrombi leads to focal impairment or cessation of the downstream blood flow, resulting in irreversible damage of the associated brain tissue. Rapid thrombolysis using tissue-plasminogen activator (t-PA, which promotes cleavage of fibrin in the thrombus) is ...
Towards a rapid diagnostic test for thrombotic thrombocytopenic purpura KU Leuven
Thrombotic Thrombocytopenic Purpura (TTP) is an orphan disease that yearly affects 10 out of 1 000 000 people worldwide. Although no Belgian patient registry exists, it can be estimated that (based on French data) in the last 15 years, 150 new TTP patients arose. Upon an acute TTP episode, patients arrive in the hospital with various complaints (purpura, fever, haemolytic anaemia, neurological manifestations, renal dysfunction…), which ...