Exploration of the therapeutic potential of protein phosphatases involved in chromatin signaling. KU Leuven
Our research group has a long-standing expertise in protein phosphatase 1 (PP1) and chromatin signaling and we want to develop chromatin-associated PP1 as a successful therapeutic target. Specific research objectives of this project are: 1. To delineate the role of PP1 in the dynamics of histone phosphorylation. 2. To identify the protein that target PP1 to histones. 3. To explore how PP1 cross-talks with other histone-modifying enzymes. 4. To ...