Projects
Exploration of the therapeutic potential of protein phosphatases involved in chromatin signaling. KU Leuven
Interference of protein phosphatase PP1 with the DNA-repair capacity KU Leuven
Cells have evolved elaborate sensing and repair mechanisms to deal with various types of DNA damage. We have found that the deletion of NIPP1, a substrate-targeting subunit of protein phosphatase PP1, dramatically increases the DNA-repair capacity. Conversely, the overexpression of PP1-NIPP1 in human cells induces numerous DNA lesions. Here, we propose to study the molecular mechanism(s) by which PP1-NIPP1 reduces the DNA-repair capacity and ...
Genome-wide promotor binding profiling of Protein phosphatase 1 and its major nuclear targeting subunits KU Leuven
Integration of cellular signaling pathways in health and disease. KU Leuven
Host cell phosphatases in the life cycle of DNA viruses KU Leuven
Screening for inhibitors of protein phosphatases that induce mitotic cell death in cancer cells KU Leuven
To this day, cancer is a prevalent disease that accounts for a significant portion of the mortality that is seen in the modern world. The taxanes and vinca alkaloids play a prominent role in the treatment of many types of cancer. These molecules kill cancer cells in mitosis by chronicly activating the spindle assembly checkpoint (SAC) and subsequently inducing mitotic cell death (MCD). However, the clinical use of these molecules has two ...