Projects
Microsen - Elucidating anti-biofouling on nanoporous gold surfaces: toward microneedle devices for continuous drug sensing. University of Antwerp
In search for anticonvulsive and antiepileptogenic neuropeptides as a strategy for innovative future antiepileptic drug development Vrije Universiteit Brussel
Outcome Measurement and Evaluation as a routine practice in alcohol and other drug services in Belgium (OMER-BE) Ghent University
The main goal of the OMER-BE study is to measure and compare recovery indicators between different treatment modalities and assess their evolution during and after treatment. In this way, the OMER-BE study will shed light on how individuals in recovery use different resources in these settings.
This research project takes the form of a longitudinal cohort study in five different treatment modalities in Flanders and Brussels: ...
HIV nuclear import and chromatin reading as novel drug targets KU Leuven
The replication cycle of HIV is a complicated interplay between viral and cellular proteins. Until now antiretroviral therapy mainly targets the viral proteins although the interaction between the viral and cellular proteins could be interesting new drug targets. This strategy is mainly of interest because cellular proteins are much less prone to mutations which gives the virus less opportunity to develop drug resistance. My laboratory has ...
Monitoring Mission Zwin Extension Ghent University
MIRASTAR2.0: Miniature Raman Spectrometer for Antibiotics Monitoring Ghent University
Antibiotics play a life-saving role in the treatment of critically ill patients in intensive care units (ICUs), who are frequently fighting against severe infections. We are developing a miniature Raman spectroscopic sensor for therapeutic drug monitoring (TDM), especially for personalized antibiotics therapy. With this project, we want to advance our on-chip Raman sensor to achieve 1 mg/L concentration measurements of the free-fraction of ...
Ferroptosis monitoring and targeting in lung ischemia-reperfusion injury from mice to human. University of Antwerp
A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cells KU Leuven
Ionized calcium (Ca2+) is the most versatile cellular messenger used by cells. Virtually all cells in the human body employ Ca2+ signals, i.e. rapid changes in intracellular Ca2+ concentration, to control cell physiological functions in response to extrinsic and intrinsic stimuli. Perturbations in Ca2+ homeostasis & dynamics vitiate physiological processes, acting as early drivers of disease progression and pathological outcomes. Hence, ...
MIRASTAR: MIniature RAman Sensor Targeting Antibiotic monitoRing Ghent University
We are developing a miniature optical sensor to measure the antibiotic concentration in blood. In this IOF ConcepTT project, we want to develop prototypes for a proof-of-concept experiment that the sensitivity of our sensor can be improved to therapeutic concentrations of β-lactam antibiotics in intensive care units