Noradrenergic modulation of seizures and epilepsy: the good, the bad and the ugly Ghent University
The locus coeruleus (LC) is a noradrenergic brainstem nucleus and the sole source of noradrenaline (NA) in the neocortex, hippocampus and cerebellum. NA exerts complex concentration dependent neuromodulatory effects, binding to a variety of different adrenoceptor subtypes with varying affinity. In this project we will investigate three hypothesized roles for the LC-NA system in seizures and epilepsy: 1) a ‘good’ role, where NA at low and ...