Publications
Nostis qui in schola Christi eruditi estis, Iacob ipsum esse Israel. Sermo 122, In Iohannis euangelium tractatus 7 and the Donatist and Pelagian Controversies KU Leuven
Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate Vrije Universiteit Brussel
STUDY QUESTION Can full spermatogenesis be achieved after xenotransplantation of prepubertal primate testis tissue to the mouse, in testis or subcutaneously? SUMMARY ANSWER Intratesticular xenotransplantation supported the differentiation of immature germ cells from marmoset (Callithrix jacchus) into spermatids and spermatozoa at 4 and 9 months post-transplantation, while in subcutaneous transplants, spermatogenic arrest was observed at 4 ...
Derivation and characterization of a cytocompatible scaffold from human testis Vrije Universiteit Brussel
Summary answer: We developed a method to produce a cytocompatible decellularized testicular matrix (DTM) while maintaining the native tissue-specific characteristics and components.
What is known already: The potential benefits of tissue-specific scaffolds consisting of naturally-derived ...
Label-free based quantitative proteomic analysis identifies proteins involved in the testis maturation of Bactrocera dorsalis (Hendel) Ghent University
Study on ecdysteroid levels and gene expression of enzymes related to ecdysteroid biosynthesis in the larval testis of Spodoptera littoralis Ghent University
Human and animal fertility studies in cystinosis reveal signs of obstructive azoospermia, an altered blood-testis barrier and a subtherapeutic effect of cysteamine in testis. Vrije Universiteit Brussel KU Leuven
A multi-organ-chip co-culture of liver and testis equivalents Vrije Universiteit Brussel
STUDY QUESTION: Is it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip?
SUMMARY ANSWER: Multi-organ-chip co-cultures of human liver and testis equivalents were maintained at a steady-state for at least 1 week and the co-cultures reproduced specific natural and drug-induced liver-testis systemic interactions.
WHAT IS KNOWN ALREADY: Current ...
Effect of recombinant human vascular endothelial growth factor on testis tissue xenotransplants from prepubertal boys Vrije Universiteit Brussel
RESEARCH QUESTION: Does recombinant human vascular endothelial growth factor (VEGF-165) improve the efficiency of human immature testis tissue (ITT) xenotransplantation?
DESIGN: ITT fragments from three prepubertal boys were cultured for 5 days with VEGF-165 or without (control) before xenotransplantation into the testes of immunodeficient mice. Xenotransplants were recovered at 4 and 9 months post-transplantation and vascularization, ...
Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis Vrije Universiteit Brussel
Research question: Is intratesticular xenotransplantation a potential ex-vivo model for studying testicular fibrosis related to Klinefelter syndrome? Study design: First, a feasibility study of an ex-vivo model to study testicular fibrosis in patients with Klinefelter syndrome was performed. Testis tissue from boys with pre-pubertal Klinefelter syndrome (n = 3) and controls (n = 2) (<18 years) was grafted to the mouse testis (n = 12) and ...