Aβ and tau pathology in the retina of Alzheimer’s disease patients and non-demented elderly individuals and its relation to the brain pathology KU Leuven
Alzheimer’s Disease (AD) is the most common form of neurodegenerative dementia in the elderly. Its complex pathogenesis is linked to the accumulation of abnormal phosphorylated τ protein and amyloid β peptide aggregates in the central nervous system. However, between the initiation of this protein aggregation and the onset of cognitive impairment, there is a gap of more than 10 years. Given that non-demented individuals already exhibit ...