Synaptic density, tau and multiparametric PET-MR for quantitative functional assessment and prognosis in stroke and mild cognitive impairment KU Leuven
There are no reliable biomarkers to predict recovery, assess prognosis or objectively monitor interventions in stroke and amnestic mild cognitive impairment (aMCI) due to Alzheimer’s disease. Two major, related pathological hallmarks common to these disorders are a decrease in synaptic connectivity, which may involve various neurotransmitters, and an accumulation of tau protein deposits. These are associated with disturbances in white matter ...