Projects
Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease. KU Leuven
CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:
- develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up ...
Multi-component nanoparticles as bimodal contrast agents for MRI and optical detection of tumors and for targeted photodynamic therapy KU Leuven
The main aim of this proposal is to synthesize a range of lanthanide containing nanoparticles with an upconverting core, that can be excited in the infrared region to yield emission in the visible range, as for MRI and optical imaging. The nanoparticles will be covered with a rare earth doped MRI active shell and decorated with targeting moieties, which offers a means of targeting cancer cells that greatly over express the receptors. Further ...
Metrology for emerging targeted alpha therapies KU Leuven
Targeted alpha therapy (TAT) is a rapidly growing cancer treatment modality, whereby alpha-emitting radiopharmaceuticals selectively target tumours whilst minimising the radiation to healthy tissues. Presently only 223RaCl2 has regulatory approval, but its success resulted in unprecedented levels of interest and investment in TAT for a variety of cancers. It is showing promising efficacy and increased survival in clinical trials; however, ...
Digital radiation therapy patient. KU Leuven
The past decade has seen a revolution in radiation therapy technology, offering exceptional flexibility in dose delivery. Image guidance during treatment ensures a reliable targeting of the dose to the tumor. This has created the possibility to irradiate the tumor with a high dose with minimal exposure of surrounding tissue. Thus an improvement in tumor control is no longer invariably associated with an increase in radiation-induced ...
UPGRADE: Unlocking Precision Gene Therapy Vrije Universiteit Brussel
iHIVARNA: Therapeutic TriMix / mRNA based Vaccine in Chronic HIV-1 Infected Patients Receiving Antiretroviral Therapy Vrije Universiteit Brussel
The GEne Therapy INnovation Training Network KU Leuven
Gene therapy has transitioned from a distant hope to reality. To date 3 rAAV gene therapies are approved in the EU, >30 phase III clinical trials ongoing, and exciting developments in therapeutic gene editing in the pipeline. However, fundamental limitations in the bioprocessing of gene therapy vectors limit broader application. Manufacturing is not automated, with an open process environment, limited scalability and robustness, and ...
Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified. KU Leuven
Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caused by a multitude of organisms that ...
NOn-VIral gene modified STEM cell therapy Ghent University
Despite the increasing awareness that cell and gene-therapy approaches have tremendous biomedical potential, their broad clinical application has been challenging due to prolonged and expensive production times and the emergence of severe immune- and gene-delivery dependent side effects. In this proposal, we aim to establish a stream-lined and high-throughput protocol for iPSC-based cell therapy by combining a novel technological platform for ...