Targeting radiotherapy resistance in Head and Neck Cancers: the potential biomarker role of TIPRL1 and CIP2A, two cellular inhibitors of Protein Phosphatase 2A KU Leuven
Being one of the main post-translational modifications, reversible protein phosphorylation is of major importance in signal transduction regulation. Over the years, the kinases phosphorylating many substrates have been extensively studied, while the protein phosphatases have been lagging behind. The PP2A-like phosphatases PP2A, PP4 and PP6, all have been shown to play a role in the regulation of tumorigenesis and the DNA damage response ...