A ‘futile’ fatty acid cycle as central mediator and exploitable target in cancer resistance to molecular targeted therapy KU Leuven
With 14 million new cases and 8 million deaths annually, cancer remains one of the major health challenges. To improve the efficacy of cancer treatment while minimizing side effects, there is a strong movement towards molecular targeted approaches, usually targeting a mutant signaling protein specifically in cancer cells. One of the major challenges related to targeted treatments is the ease with which tumors escape therapies, despite an ...