Projects
Beyond optimising drug exposure: Pharmacodynamic models to bridge the gap between exposure and response to antimicrobial treatments KU Leuven
Dosage regimens are based on randomised controlled trials that usually do not represent the heterogeneity of the final intended real-world treatment population well. Real-world variability in drug exposure is common and can result in suboptimal treatment. To hit a predefined exposure target in each patient, pharmacokinetic (PK) monitoring can be implemented. PK monitoring facilitates the attainment of a desired exposure target by guiding ...
Pharmacometric models for improved therapeutic drug monitoring of ceftriaxone, posaconazole and infliximab KU Leuven
In clinical drug development, “one dose fits all” is a key objective. However, variability in exposure (E) and response (R) is common and can result in suboptimal treatment of individual patients. To hit a predefined E/R target in each patient, “therapeutic drug monitoring” or TDM is often implemented. TDM helps improving attainment of a desired E/R target by guiding individualised drug dosing based upon drug concentrations. “Population ...
PHD ON POPULATION PK MODELING OF TACROLIMUS AND COMPUTER ASSISTED DOSE FINDING INCLUDING SOFTWARE DEVELOPMENT AND TESTING (PROOF OF CONCEPT) KU Leuven
Tacrolimus is the mainstay of immunosuppressant therapy after solid organ transplantation. The goal of this project is to develop an intuitive dose finding software of tacrolimus computing future doses from the known dosing regimen and individual plasma concentrations of tacrolimus. More specifically, this project includes: 1. The systematic collection of data in databases: treatment regimen modalities, serum concentrations, covariates and ...
Improving maternal health outcomes in Ethiopia by integrating of point-of-care testing for sexually transmitted infections in antenatal care Ghent University
The project primary aims are to tackle neonatal and maternal mortality and morbidity and to improve quality of postgraduate education on women’s health through advanced research. These goals respond to the sustainable development goals (SDG) 3.2 (reducing under-5 years mortality), SDG 3.8 (universal access to effective treatment) and SDG 4 (quality education). Although Ethiopia has made strides in reducing maternal and childhood mortality, ...
SYN-CAT: SYNergetic design of CATalytic materials for integrated photo-and electrochemical CO2 conversion processes Catalisti
CO2 conversion
Currently, highly active and selective catalysts are under development to convert CO2 into CO. For the conversion of CO2 into other target chemicals, such as dimethoxy ethane (DME) and methanol (MeOH), further innovations are required.
Major challenges
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Development and streamlining a validation and implementation workflow for model-informed precision dosing for biologicals and antimicrobials KU Leuven
Ex-OKAN + French = défi Karel De Grote Hogeschool
Industrial policy-making in mineral-rich developing countries KU Leuven
This dissertation investigates policy-making in mineral-rich developing countries with a focus on policies that seek to promote the value add to mineral products before export (also known as beneficiation policy). Firstly, it explores how mineral value chains may be conceptualised to frame the debate around beneficiation policy and enable a holistic contextualisation of such policy. Secondly, it presents two novel/adapted analytical ...
ANTIBACTERIAL DOSING IN SPECIAL PATIENT POPULATIONS WITH SEVERE BACTERIAL INFECTIONS: A PATIENT-ORIENTED AND COVARIATE-DRIVEN APPROACH KU Leuven
Early and appropriate antibiotic therapy are crucial determinants for successful treatment of severe bacterial infections. Suboptimal antibiotic exposure has been shown to lead to worse clinical outcome (e.g., prolonged antibiotic course, prolonged length of stay, increased mortality). Hence, antibiotic exposure should be high enough to maximize the likelihood of clinical success, but not too high to avoid unnecessary toxicity. Beta-lactams ...