Circulating tumor DNA as an epigenetic marker of tumor behaviour KU Leuven
Specific tumor characteristics, such as molecular expression subtypes and hypoxia status, represent major predietors of patient prognosis and therapy response. For instance, patients with HER2-enriched breast tumor subtypes have a 2- fold increased risk of mortality, but uniquely benefit from Herceptin treatment. Likewise, hypoxic tumors are more prone to metastasis and show poor treatment responses. The routine detection of tumor subtypes or ...