Publications
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Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels Ghent University
TRAFFICKING OF TRP CHANNELS KU Leuven
TRP channels form a very large family of ion channels, with 28 members in mammals, that all conduct cations. These ion channels are present in almost all mammalian cells, where they perform various functions to sustain the proper physiology of cells and organisms. One of the main features of TRP channels is that they can be activated by many different kinds of stimuli. Over last fifteen years, researchers have described the mechanisms whereby ...
TRP channels in neurogastroenterology: opportunities for therapeutic intervention KU Leuven
The members of the superfamily of transient receptor potential (TRP) cation channels are involved in a plethora of cellular functions. During the last decade, a vast amount of evidence is accumulating that attributes an important role to these cation channels in different regulatory aspects of the alimentary tract. In this review we discuss the expression patterns and roles of TRP channels in the regulation of gastrointestinal motility, enteric ...
The role of heat-activated TRP channels in pain and inflammation KU Leuven
Acute pain is unpleasant but physiologically relevant. When pain is triggered to protect us from a potentially dangerous situation, the benefits of pain outweigh the drawbacks. Chronic pain has, in contrast to acute pain, lost its protective function and persists long after the initial cause. Despite intensive research, the underlying molecular and cellular basis of chronic pain remains poorly understood. The search for new analgesic drugs with ...
Role of TRP ion channels in cancer and tumorigenesis KU Leuven
Transient receptor potential (TRP) channels are recently identified proteins that form a versatile family of ion channels, the majority of which are calcium permeable and exhibit complex regulatory patterns with sensitivity to multiple environmental factors. While this sensitivity has captured early attention, leading to recognition of TRP channels as environmental and chemical sensors, many later studies concentrated on the regulation of ...
TRP channels and mechanosensory transduction: insights into the arterial myogenic response KU Leuven
Mechano-gated ion channels are implicated in a variety of key physiological functions ranging from touch sensitivity to arterial pressure regulation. Seminal work in prokaryotes and invertebrates provided strong evidence for the role of specific ion channels in volume regulation, touch sensitivity, or hearing, specifically the mechanosensitive channel subunits of large and small conductances (MscL and MscS), the mechanosensory channel subunits ...
TRP channels in the skin KU Leuven
Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In ...
TRP Channels KU Leuven
TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 different TRP channel genes have been identified, which exhibit a large variety of functional properties and play diverse cellular and physiological roles. In this article, we provide a brief and systematic summary of expression, function, and ...
TRP Channels and Pruritus KU Leuven
Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators, itch-selective pruriceptors, sensory afferent networks, spinal cord neurons, and certain central nervous system regions. In this review, we first introduce major features of the pruriceptive ...