Projects
Identification, characterization and validation of modifiers of repeat RNA toxicity in C9orf72 amyotrophic lateral sclerosis (ALS) KU Leuven
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the degeneration of upper and lower motor neurons in the motor cortex, brainstem and spinal cord. With an average survival of 3-5 years and a lack of effective therapies, there is a high unmet medical need for new therapeutic interventions. The most frequent genetic cause of both familial (40%) and sporadic ALS (4%) is caused by a non-coding repeat ...
FORX - FOod interventions to Reduce immunotherapy toXicity Vrije Universiteit Brussel
Promotor: Sandrine Aspeslagh
Investigating fatty acid toxicity in amyotrophic lateral sclerosis KU Leuven
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease of the adult motor system. In 2040, the number of ALS patients will increase by 69%, making it urgent to develop new treatments. ALS is characterized by the loss of upper and lower motor neurons, leading to progressive paralysis and, inevitably, death within 3 to 5 years of diagnosis. Hyperexcitability is a common pathologic feature and is associated with a worse ...
Effects of the chemical structure of per- and polyfluoroalkyl substances (PFAS) on the bioaccumulation and toxicity to terrestrial and aquatic plants and invertebrates. University of Antwerp
0ASIS: Oxyanions bioavailability and toxicity in aquatic ecosystems - development of novel speciation tools for the determination of ArSenIc and Selenium Vrije Universiteit Brussel
Investigating astrocyte toxicity in amyotrophic lateral sclerosis using human motor units KU Leuven
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of both upper and lower motor neurons (MNs). In this regard, in the last years the non-cell autonomous contribution of reactive astrocytes has been considered as extremely influential to the course of the pathology. Unfortunately, in-vitro 2D cultures and mouse models are not capable to fully recapitulate molecular pathological features and motor ...
Prediction of immunotherapy response and toxicity in melanoma, renal cell and lung cancer using transcriptome based systemic immune phenotyping. Ghent University
An increasing number of cancer patients undergoes treatment with immune checkpoint inhibitors (ICIs), hence, only a fraction of the patients will respond. Nevertheless, existing predictive biomarkers cannot accurately discriminate non-responder from responder patients and require invasive tumor tissue sampling. A group of these ICI treated patients develop immune-related adverse effects (irAEs). Also for irAEs no accurate prediction ...
Bio-imaging and size determination of combustion-derived particles to assess their toxicity following transplacental translocation from mother to fetus. Hasselt University
Hepatic toxicity modeling and prediction: focus on drug-induced cholestasis Vrije Universiteit Brussel
These virtual research groups are established with the help of efficient coordination and intensive collaboration at (inter) national level. They prevent double use and offer researchers more development ...