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Monsters of the Apocalypse: A link between Anoxia, Mutation, Extinction, and Stratabound REE Ores Ghent University

Thijs Vandenbroucke
Department of Geology, United States Geological Survey, Indiana University

Ordovician-Silurian mass-extinctions shaped the evolution of Earth’s biosphere. New data from these events record abrupt changes in the marine C-cycle and global climate that challenge the strongly held cause-and-effect relationship between cooling (glaciation) and extinction. Through a pilot study we have discovered a striking correlation between severely malformed organic-walled fossil plankton and dramatic increases in redox-sensitive ...

Bioactivation of human proteratogens in the zebrafish embryo model, a potential alternative test for development toxicity assessment. University of Antwerp

Steven Van Cruchten
Natural Products and Food - Research and Analysis (NatuRA), Molecular, Cellular and Network Excitability (MCNE), Comparative Perinatal Development (CoPeD)
Within Europe, alternative methods for toxicity assessment of xenobiotics become very important. For developmental toxicity, the mouse Embryonic Stem Cell test and the rat Whole Embryo Culture are commonly used, but assays in non-mammalian whole organisms are currently proposed as they more fully represent the complexity of early development. The zebrafish (Danio rerio) is one of the preferred species due to their small size, high fecundity and ...

Dental pulp stem cells as an innovative tool to specifically target angiogenesis in oral squamous cancer Hasselt University

Annelies BRONCKAERS
Morphology
Head and neck squamous cell cancers (HNSCC) are among the most prevalent tumors in the world. Despite recent advances in treatment, the survival rate of patients has remained incredibly poor and unchanged during the past 30 years. The aggressive behavior of HNSSC is associated with angiogenesis, indicating that inhibiting this phenomenon would provide an effective therapy. Emerging evidence indicates that bone-marrow mesenchymal stem cells ...

Dental pulp stem cells as an innovative tool to specifically target angiogenesis in head and neck squamous cell cancers. Hasselt University

Ivo LAMBRICHTS
Morphology
Head and neck squamous cell cancers (HNSCC) are among the most prevalent tumors in the world. Despite recent advances in treatment, the survival rate of patients has remained incredibly poor and unchanged during the past 30 years. The aggressive behavior of HNSSC is associated with angiogenesis, indicating that inhibiting this phenomenon would provide an effective therapy. Emerging evidence indicates that bone-marrow mesenchymal stem cells ...