Development of proteomics workflows and study of the mechanism for secretion through T3SS in Enteropathogenic E.coli (EPEC) KU Leuven
Bacteria have evolved sophisticated nano-machines that allow them to perform specialized functions. Among these are protein secretion systems making feasible the protein translocation from the cell cytoplasm to the extracellular environment. One such nanomachine is the Type III protein secretion system (T3SS), a ~ 3-4 MDa structure composed by more than 20 proteins. T3SS penetrates both membranes of Gram-negative bacteria and extends a ...