Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells. Ghent University
Department of Diagnostic Sciences, Department of Data analysis and mathematical modelling, Department of Biomolecular Medicine
T-cell acute lymphoblastic leukemia (T-ALL) is a cancer that arises in normal blood cells and hijacks normal T-cell development pathways to cause a malignant disease. Normal T-cell development is well studied and the majority of genomic changes that occur in T-ALL are known. From these data, there is clear evidence that chromatin structure, transcription and translation are major processes that are deregulated in T-ALL, but how specific ...