Projects
Creation, development and validation of an experimental protocol to obtain paired T-cell receptor alpha and beta data from FFPE tissue at a single cell level. University of Antwerp
Targeting the leukemic cancer stam cell in early T-cell precursor Acute Lymphoblastic Leukemia (ETP-ALL) Ghent University
The abstract for "Targeting the leukemic cancer stam cell in early T-cell precursor Acute Lymphoblastic Leukemia (ETP-ALL) " is missing. Please contact the promotor for more information.
Unraveling the role of PHF6 in normal T cell development and T-cell acute leukemia Ghent University
T-cell acute lymphoblastic leukemia (T-ALL) arises from malignant transformation of precursor T-cells and often affects children. In the search for novel genetic defects in this cancer, PHF6 was recently identified as a novel tumor suppressor gene in T-ALL. In this project, the cellular function of PHF6 and its role in normal T-cell development and T-ALL will be investigated.
Study Of Cooperating Oncogenes In The Development Of T-Cell Acute Lymphoblastic Leukemia Using CRISPR/Cas-Generated Cell And Mouse Models. KU Leuven
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease, which arises from the malignant transformation of developing T-cell progenitors. Survival rates are nowadays up to 90% in children and 40% in adults. However, current therapy is associated with many short-term and long-term side effects, and survival rates after relapse or primary resistance remain very low. To address this challenge, current research is ...
Evaluation of highly immunogenic tumor cell vaccines in combination with regulatory T-cell depletion Ghent University
The aim of this project is to enhance the efficacy of tumor cell vaccines by increasing their immunogenicity and by combining the tumor cell vaccines with a depletion of regulatory T-cells. We will optimize this new vaccination strategy in tumor bearing mice. Subsequently, the most effective cancer vaccination protocol will be evaluated in dogs with cancer.
Unraveling the role of PHF6 in normal T cell development and T-cell acute lymphoblastic leukemia Ghent University
This research project aims to unravel the role of the tumorsuppressor gene PHF6 in normal T-cell development and T-ALL and identifying the transcriptional networks in which PHF6 is involved. Additional proteomics analyses will be applied to characterize the transcriptional complex in which PHF6 participates. This project aims on longer terms to identify new molecular targets for treatment of T-ALL patients.
Role of eicosanods in T-cell and dendritic cell activation in chronic rhinosinusitis/nasal polyposis with specialattention to aspirin exacerbated respiratory disease (AERD) Ghent University
AERD constitute a severe form of airway inflammation within the group of patients with nasal polyposis and steroid-dependent asthma. We suggest that the development of the disease is linked to a disregulation of T-cell/DC function and an imbalance in the eicosanoid metabolism. The objective of the work is unravel the role of eicosanoids and aspirin desensitization on T-cel/DC differentiation/activation.