Functional heterogeneity in T-cell acute lymphoblastic leukemia Ghent University
The emergence of relapse resistant to chemotherapy is the major obstacle preventing the cure of
cancer. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for
15% of pediatric and 25% of adult acute lymphoblastic leukemia cases. Although genomic studies
have shed light on the genetic mechanisms driving disease development as well as recurrence
following therapy, ...