Targeting aberrant DNA methylation in T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) Ghent University
T-cell acute lymphoblastic leukemia and lymphoma (T-ALL/T-LBL) are aggressive hematologic malignancies that arise from malignant transformation of T-cell progenitors. T-ALL/T-LBL patients are currently treated with high-dose chemotherapy potentially followed by hematopoietic stem cell transplantation. Recently, we have shown that DNA methylation profiles of human T-ALL are uniformly perturbed as compared to normal human thymic precursor ...